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Tag Archives: androgen deprivation

Combining Radiation Therapy and Androgen Deprivation for Localized Prostate Cancer – A Critical Review

Photo Credit: Wikimedia Commons.

Summary by Dr. Luis Souhami MD – McGill University Health Centre

In our paper we critically reviewed major publications that evaluated the use of radiation therapy (RT) combined with androgen deprivation for localized prostate cancer. Also, a brief summary of some important preclinical studies was made in order to reinforce a better understanding of the biological basis for this approach.  For didactic purposes, we have clustered prospective randomized trials in two major groups: one including studies basically testing hormonal therapy before RT (neoadjuvant therapy) and other using hormonal therapy concomitantly and/or after RT. Based on this scheme, we endeavoured to properly define most appropriate treatment recommendations for each risk category.

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