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Tag Archives: brain tumor

Novel subgroups for clinical classification & outcome prediction in childhood medulloblastoma

by Edward C Schwalbe, Janet C Lindsey, Sirintra Nakjang, Stephen Crosier, Amanda J Smith, Debbie Hicks, Gholamreza Rafiee, Rebecca M Hill, Alice Iliasova, Thomas Stone, Barry Pizer, Antony Michalski, Abhijit Joshi, Stephen B Wharton, Thomas S Jacques, Simon Bailey, Daniel Williamson, Steven C Clifford.


Originally published in The Lancet Oncology, May 22nd 2017


Medulloblastoma, the most common CNS tumor of childhood, is the leading cause of cancer deaths in young people. What was once thought of as a single disease is, since an International consensus meeting in 2012, now recognized as four distinct molecular entities (WNT, SHH, Grp3, Grp4), each defined by differing disease features and outcomes. However, the studies that defined this consensus were based on small cohorts of tumors, and were performed using low-resolution approaches.


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Grassroots Funding Imperative for Childhood Cancer Research

childhoodcancerawarenessby Sue McKechnie, CKN Editor


Kristine Laplante could not believe it when her 6 month old daughter Evie was diagnosed with a brain tumour.  “She had this crazy eye twitch that led us to our family doctor” says Kristine. “We learned that she had a cancerous brain tumour called a Hypothalamic Optic Glioma. Our lives were forever changed in that moment.”  Evie is now 6 years old and has been on chemotherapy for most of her life. “There is currently no cure. Treatment is geared towards slowing the growth of the tumour until the research catches up.”


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The Long Road to Hope for Children with DIPG

JonathanAgin2by Jonathan Agin, Co-Editor, Childhood Cancer Advocacy


In 2008, when our twenty-seven month old daughter Alexis was diagnosed with something called DIPG, or diffuse intrinsic pontine glioma, I knew nothing about the world of childhood cancer or even the terror that those letters cause.  Alexis was by all accounts a normally developing child.  She enjoyed music, TV shows, blowing bubbles, art projects and so much more.  She ran, she jumped, she played and she was going to her first nursery school program.  There was an issue for several months when she was vomiting at night, as well as a very slight and intermittent concern with her right eye turning inward. What we anticipated to be nothing more than lazy eye turned out to be a pediatric brain tumor.

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Pediatric Brain Cancer: Collin’s Courageous Story

JonathanAgin2Intro by Jonathan Agin, Childhood Cancer Co-Editor

As I type, there is a mother and a father, or a single parent or caregiver being brought into a cramped little room in a hospital and the feeling of fear is palpable.  Four words will be said in that room that will cause the lives brought together there to change forever: “your child has cancer.”  It is a story that repeats itself over and over again with increasing frequency.  In the United States, more than 15,000 children a year are diagnosed.  In Canada, the number is approximately 1,500 children a year that are diagnosed.  In the United States, childhood cancer is the number one disease killer of children, in Canada, the second largest cause of death by disease for children under the age of fifteen.  Despite how those numbers appear given the respective populations, childhood cancer is not some distant concept that knocks on the doors of the unlucky.  Rather, it is a biological disease that has many different forms that is all too real, and all too devastating.  The following story about Collin’s diagnosis, treatment and life is one of fear, caution and hope.  Collin’s family heard the horrible knock on their door despite never expecting it and is fighting for survival every day.  My family heard that knock too, but unfortunately for my wife and I, there was not to be any happily ever after.

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Childhood Cancer: Why You Should Care

goldribbonby Tami Moscoe, Co-Chair, Lilah’s Fund for Neuroblastoma Research @ SickKids

Each year, jurisdictions across North America recognize September as Childhood Cancer Awareness Month.  Last year, both the CN Tower and Niagara Falls were lit up in gold, and children across Ontario chalked up their schools to mark this important event, thanks to our friends at POGO (the Pediatric Oncology Group of Ontario) and Crayola.

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