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Tag Archives: ed schwalbe

Novel subgroups for clinical classification & outcome prediction in childhood medulloblastoma

by Edward C Schwalbe, Janet C Lindsey, Sirintra Nakjang, Stephen Crosier, Amanda J Smith, Debbie Hicks, Gholamreza Rafiee, Rebecca M Hill, Alice Iliasova, Thomas Stone, Barry Pizer, Antony Michalski, Abhijit Joshi, Stephen B Wharton, Thomas S Jacques, Simon Bailey, Daniel Williamson, Steven C Clifford.

 

Originally published in The Lancet Oncology, May 22nd 2017

 

Medulloblastoma, the most common CNS tumor of childhood, is the leading cause of cancer deaths in young people. What was once thought of as a single disease is, since an International consensus meeting in 2012, now recognized as four distinct molecular entities (WNT, SHH, Grp3, Grp4), each defined by differing disease features and outcomes. However, the studies that defined this consensus were based on small cohorts of tumors, and were performed using low-resolution approaches.

 

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