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Tag Archives: preservation

Fertility Preservation Options


Preserving reproductive options BEFORE and DURING cancer treatments

Many current fertility preservation techniques require Controlled Ovarian Stimulation (COS) prior to oocyte or embryo banking.  Important information about COS includes:Early referral to a fertility specialist is important
Controlled Ovarian Stimulation (COS) – General Information

  • Pre-cycle considerations
  • Medications
  • General protocol information
  • Cryopreservation strategies
  • Additional Considerations for COS in cancer patients


  • Is COS safe in women with cancer?
  • Is COS safe in women with hormone-sensitive cancers?

Protocol challenges

  • Which exact stimulation protocol is best?
  • How can we rapidly induce a menstrual cycle?
  • Are IVF cycles different for women with cancer?
  • Can a patient undergo COS after receiving chemotherapy?

Chance of pregnancy after embryo cryopreservation

  • Considerations
  • Can we give a blanket estimation of future pregnancies?
  • Society for Reproductive Technology (SART) Database

Chance of pregnancy after oocyte cryopreservation

Fertility preservation options are also available that do not require hormonal stimulation:

Reproductive options AFTER cancer

Pregnancy Rates After Cancer
Several factors need to be accounted for when predicting the change of future pregnancy when banking embryos or eggs. First of all, one must consider the anticipated ‘success’ of a controlled ovarian stimulation (COS) procedure, in terms of stimulation characteristics, oocyte yield, fertilization rates, etc. Next, it is important to predict actual pregnancy rates from cryopreserved oocytes or embryos per transfer cycle.Assessing ovarian reserve

  • What does the literature tell us?
  • Childhood cancer survivor study
  • Models to predict premature menopause
  • What does the presence or absence of menses indicate?


When and how should a frozen embryo transfer occur?

  • When is it safe to consider pregnancy?
  • What protocol is best for frozen embryo transfers in women with hormone-sensitive cancers?

Logistics and safety of pregnancy after cancer

  • Safety of pregnancy:  recurrence risk
  • Safety of pregnancy:  offspring
  • Timing of pregnancy


The information provided on the CKN website is designed to support, not replace, the relationship that exists between a patient and his/her physician.  CKN thanks the Oncofertility Consortium and Save My Fertility for providing content on this page. If you’d like more information, or to make a suggestion: Contact us.

Oncofertility Education Modules: A presentation by Dr. Hananel Holzer


Resident Module – Fertility#1

Resident Module – Fertility#2a

Resident Module – Fertility#2b

Resident Module – Fertility#3



by Monisha Sudarshan, MD

As one walks into Dr.Holzer’s office, his passion and love for helping patients with fertility issues is clear. Among the many honors and thank you notes, sits a small decorative baby carriage with the words engraved “Doctors are known to heal, you are known to create miracles”. Dr. Holzer is the Medical Director of the MUHC (McGill University Health Centre) Reproductive Centre and one of the pioneers in oncofertility. In fertility management, he describes every couple as a “new story” however, oncofertility presents its own unique challenges and complexities for the patient and physician population. Dr.Holzer advises his patients that the first and foremost importance is to fight the cancer; fertility represents an important aspect but is not the primary priority. One of his goals is also to educate and bring awareness to cancer physicians and residents about the options of fertility preservation for the younger oncology population and is working on creating easy, timely access for referral of these patients to expert centers. Continuing his educational endeavour, he has designed expert teaching modules targeted for resident education in oncology and fertility and to spark interest in this interesting and rapidly growing field. Modules begin with basic physiological changes with chemotherapy and radiotherapy, progress to current options in fertility preservation and the experience at the McGill University Health Center. Continue to stay tuned for more knowledge on this important and stimulating topic within oncology.