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Tag Archives: prostate

Improving Patient Outcomes in Advanced Prostate Cancer

prostateCurrent Oncology Special Supplement:  Read the articles here.

Editorial by F. Saad , MD

It was with a great deal of pride that I accepted to be the guest editor of this Current Oncology supplement dedicated to prostate cancer. It is especially exciting to realize that the whole supplement was able to be based on data that has only recently been published or that is still unpublished.

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Do Recent Studies Demonstrate New Uses For an Age-Old Idea?

by Jonathan Klein, M.D

The April 2011 edition of the International Journal of Radiation Oncology, Biology, and Physics, colloquially known as “The Red Journal,” contained a potentially provocative article by Ashamalla et al. from Weill Medical College of Cornell University. In it, the authors reported on a study they performed using acupuncture to treat hot flashes in men undergoing androgen deprivation therapy for prostate cancer. Using a validated scoring method, which grades hot flashes by multiplying their frequency times their severity, they report that the mean Hot Flash Score (HFS) reported by the 14 patients in their study dropped from 28.3 before treatment to 10.3 at 2 weeks post-treatment, 7.5 at 6 weeks, and 7.0 at 8 weeks; these results were reported to be statistically significant in all cases.

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Combining Radiation Therapy and Androgen Deprivation for Localized Prostate Cancer – A Critical Review

Photo Credit: Wikimedia Commons.

Summary by Dr. Luis Souhami MD – McGill University Health Centre

In our paper we critically reviewed major publications that evaluated the use of radiation therapy (RT) combined with androgen deprivation for localized prostate cancer. Also, a brief summary of some important preclinical studies was made in order to reinforce a better understanding of the biological basis for this approach.  For didactic purposes, we have clustered prospective randomized trials in two major groups: one including studies basically testing hormonal therapy before RT (neoadjuvant therapy) and other using hormonal therapy concomitantly and/or after RT. Based on this scheme, we endeavoured to properly define most appropriate treatment recommendations for each risk category.

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