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Understanding and overcoming chemoresistance in ovarian cancer: emerging role of the endothelin axis

by A. Bagnato, L. Rosanò

Epithelial ovarian cancer ( eoc ) is the leading cause of gynecologic cancer mortality worldwide.  The drug-resistant nature of eoc cells means that effective chemotherapies are lacking, which contributes to the high mortality in patients diagnosed with eoc 1. This disappointing situation strongly suggests that improved understanding of the drug-resistance mechanistic underpinnings of eoc could lead to the development of novel therapeutic strategies for successful treatment of patients.

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